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Season Two
James Earl Jones as Mover, Serak the Preparer and the Narrator in "Treehouse of Horror"
Danny DeVito as Herbert Powell in "Oh Brother, Where Art Thou?"
Tracey Ullman as Sylvia Winfield and Emily Winthropp in "Bart's Dog Gets an F"
Season Three
Magic Johnson as Himself in "Homer Defined"
Sting as Himself in "Radio Bart"
Season Four
Bob Hope as Himself in "Lisa the Beauty Queen"
Elizabeth Taylor as Maggie Simpson in "Lisa's First Word"
Leonard Nimoy as Himself in "Marge vs. the Monorail"
Season Five
George Harrison as Himself in "Homer's Barbershop Quartet"
Kathleen Turner as Stacy Lovell in "Lisa vs. Malibu Stacy"
James Taylor and Buzz Aldrin as Themselves in "Deep Space Homer"
Season Six
Winona Ryder as Allison Taylor in "Lisa's Rival"
James Earl Jones as the voice of Maggie Simpson in "Treehouse of Horror V"
Meryl Streep as Jessica Lovejoy in "Bart's Girlfriend"
Patrick Stewart as Number One in "Homer the Great"
Mel Brooks as Himself and Susan Sarandon as the Ballet Teacher in "Homer vs. Patty & Selma"
Season Seven
Mickey Rooney as Himself in "Radioactive Man"
Glenn Close as Grandma Mona Simpson in "Mother Simpson"
Kirk Douglas as Chester J. Lampwick in "The Day the Violence Died"
Sonic Youth as Themselves in "Homerpalooza"
Season Eight
Jack Lemmon as Frank Ormand in "The Twisted World of Marge Simpson"
Willem Dafoe as The Commandant in "The Secret War of Lisa Simpson"
Season Nine
Martin Sheen as the "real Principal Seymour Skinner" in "The Principal and the Pauper"
Stephen Jay Gould as Himself in "Lisa the Skeptic"
Jay Leno as Himself in "The Last Temptation of Krust"
Jerry Springer as Himself in "Treehouse of Horror IX"
Season Ten
Robert Englund as Freddy Krueger in "Treehouse of Horror IX"
Alec Baldwin, Kim Basinger and Ron Howard as Themselves in "When You Dish upon a Star"
Rupert Murdoch and Dolly Parton as Themselves in "Sunday, Cruddy Sunday"
Season Eleven
John Goodman as Meathook in "Take My Wife, Sleaze"
Tim Robbins as Jim Hope in "Grift of the Magi"
Britney Spears as Herself in "The Mansion Family"
Season Twelve
Drew Barrymore as Sophie, and Stephen King and John Updike as Themselves in "Insane Clown Poppy"
Edward Norton as Devon Bradley in "The Great Money Caper"
Michael Keaton as Jack Crowley in "Pokey Mom"
NSYNC as Themselves in "New Kids on the Blecch"
Season Thirteen
Pierce Brosnan as the Ultrahouse 3000's Pierce Brosnan voice and Matthew Perry as the Ultrahouse 3000's Matthew Perry voice in "Treehouse of Horror XII"
Paul Newman as Himself in "The Blunder Years"
Ben Stiller as Garth Motherloving in "Sweets and Sour Marge"
Reese Witherspoon as Greta Wolfcastle and Wolfgang Puck as Himself in "The Bart Wants What It Wants"
Carmen Electra as Herself in "The Frying Game"
Season Fourteen
Eric Idle as Declan Desmond in "'Scuse Me While I Miss the Sky"
Andy Serkis as Cleanie and David Byrne as Himself in "Dude, Where's My Ranch?"
Season Fifteen
Michael Moore as Himself in "The President Wore Pearls"
Tom Clancy, Thomas Pynchon, Mary-Kate and Ashley Olsen as Themselves in "Diatribe of a Mad Housewife"
Simon Cowell as Henry, also himself over the credits in "Smart and Smarter"
Matt Groening as Himself in "My Big Fat Geek Wedding"
Season Sixteen
James Caan and Thomas Pynchon as Themselves in "All's Fair in Oven War"
50 Cent as Himself in "Pranksta Rap"
Stephen Hawking as Himself in "Don't Fear the Roofer"
Liam Neeson as Father Sean in "The Father, The Son, and The Holy Guest Star"
Season Seventeen
Alec Baldwin as Caleb Thorn in "Bonfire of the Manatees"
Dennis Rodman as Himself in "Treehouse of Horror XVI"
William H. Macy as Himself in "Homer's Paternity Coot"
Susan Sarandon as Herself in "Bart Has Two Mommies"
Frances McDormand as Melanie Upfoot in "Girls Just Want To Have Sums"
Larry Hagman as Wallace Brady and Melanie Griffith as Herself in "The Monkey Suit"
Season Eighteen
Kiefer Sutherland as The Army Colonel in "G.I. (Annoyed Grunt)"
Tom Wolfe, Gore Vidal and Jonathan Franzen as Himself in "Moe'N'a Lisa"
Natalie Portman as Darcy in "Little Big Girl"
Meg Ryan as Dr. Stacy Swanson, Stephen Sondheim as Himself, Peter Bogdanovich as Psychologist in "Yokel Chords"

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Amy Pitt -
You are a comedic genius and I miss you. Get a hold of me.
Jessica
Jessica, Casstown, USA
Actually if you read the introduction to these cameo articles, it explains:
Our selection is made up of one-off cameos, not including semi-regular guest stars such as Kelsey Grammer, Phil Hartman, Marcia Wallace and Joe Mantegna, or even occasional guest appearances by Stephen Hawking, Glenn Close, Eric Idle and James Earl Jones (who have all appeared in three episodes).
Jennie, London,
Just wanted to let you know--that wasn't the voice of Johnny Cash as the Coyote (when Homer was in the desert), it was Waylon Jennings....Kerry, USA Florida Ps--How could you forget Rodney Dangerfield as Larry Burns? LOL
kerry, Miami,
Isabella Rossellini and Jasper Johns convincing Homer he's an outsider art artist.
Amy Pitt, Lebanon, USA Ohio
You have missed out the best cameo(s) performance - Kelsey Grammer (Frasier) as Sideshow Bob and David Hyde Pierce (Niles) as his brother Cecil. Marvellous episode. Shame on you for missing it!
JB, Stockholm,
Surely Rodney Dangerfield as Larry Burns?
One of USA's greatest performers
Jon Pollard, Milton Keynes, UK